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Athione S -transferase activity, and lipid peroxidation was observed in liver and brain. Exposure to toluene, one of the gasoline constituents, both in vivo and in vitro, leads to reactive oxygen species formation in many tissues including brain tissue [36-38]. The study of Calder -Guzm et al [39] revealed that the aldehydes resulting from the oxidation of the methyl groups in the aromatic compou
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Mor microenvironment and its role in promoting tumor growth. Oncogene. 2008;27(45):5904?2. 52. Zamarron BF, Chen W. Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci. 2011;7(5):651?. 53. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646?4. 54. Joven J, Guirro M, Marine-Casado R, Rodriguez-Gallego E, Menendez JA.
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Ive behaviour in male rats.Parameter GROUP Tooth chattering Control Leaded gasoline Unleaded gasoline 1.2 ?0.33 3.7 ?0.63 a* 4 ?0.87 a* Number of aggression events Threat posture 1.1 ?0.31 3.9 ?0.43 a** 3.6 ?0.87 a* Leaping and biting 0.9 ?0.35 3.7 ?0.58 a** 3.4 ?0.70 a* Boxing position 0.8 ?0.25 2.7 ?0.47 a* 3.2 ?0.74 a**Values are expressed as means ?SE a: significantly different from the contro
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Mor microenvironment and its role in promoting tumor growth. Oncogene. 2008;27(45):5904?2. 52. Zamarron BF, Chen W. Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci. 2011;7(5):651?. 53. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646?4. 54. Joven J, Guirro M, Marine-Casado R, Rodriguez-Gallego E, Menendez JA.
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Ither the leaded or unleaded group as compared with the control. On the contrary, dopamine was elevated in the cerebellum of leaded exposed group above both the unleaded gasoline and control. The fluctuations in the levels of dopamine in different brain areas may be related to the effects MMT which is an organic manganese (Mn) compound added to unleaded gasoline and the mechanisms of Mn neurotoxic
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Nnervations reaches out to the hypothalamus to regulate secretion of TRH and prolactin secretion, and then projects to the brain limbic system to modulate motivations and emotions [47]. So, gasoline induced impairment of the DA system would result in serious impacts on the neural control of voluntary locomotion and would affect several behavioural aspects.In the present study, the norepinephrine l
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D that volatile solvents such as benzene, a main constituent of gasoline fuel, seems to interact with the synthesis and catabolism of catecholamines and serotonin in the brain, which might explain the neurotoxic effects of these solvents [53]. In this regard, deficiencies of serotonin or other monoamine neurotransmitters such as dopamine and norepinephrine are linked with depression [54,55]. In re
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D that volatile solvents such as benzene, a main constituent of gasoline fuel, seems to interact with the synthesis and catabolism of catecholamines and serotonin in the brain, which might explain the neurotoxic effects of these solvents [53]. In this regard, deficiencies of serotonin or other monoamine neurotransmitters such as dopamine and norepinephrine are linked with depression [54,55]. In re