Ory agents produced from hematomas may cause the breakdown of blood-brain barrier, that is a proposed mechanism of edema (Wagner et al., 1998). Uncontrolled irritation contributes to brain edema and prostacyclin PGI2 has been described to contribute by augmenting the permeability of capillaries (Masada et al., 2001; Xi et al., 2001, 2002; Bentzer and Grande, 2004). Subsequent experimental lipopoly